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KMID : 0366220110460010045
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Korean Journal of Hematology
2011 Volume.46 No. 1 p.45 ~ p.48
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Slow, but complete, resolution of mitomycin-induced refractory thrombotic thrombocytopenic purpura after rituximab treatment
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Hong Mi-Jin
Lee Hong-Ghi
Hur Mi-Na
Kim Sung-Yong
Cho Yo-Han
Yoon So-Young
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Abstract
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Thrombotic thrombocytopenic purpura (TTP) is a critical complication of treatment with mitomycin C. We retrospectively describe the case of a patient with progressive renal cell carcinoma and mitomycin-induced TTP refractory to plasma exchange and glucocorticoids; we describe the clinical course, successful management of TTP with rituximab, and follow-up of this case. Mitomycin-induced TTP resolved completely by a total of 4 infusions of rituximab 375 mg/m2 on a weekly basis, and it took up to 12 months to obtain a platelet count of ＞100,000/mL. Rituximab is indicated for the treatment of mitomycin-induced TTP refractory to plasma exchange and glucocorticoids, and it could improve the patient’s quality of life despite the presence of underlying malignancy.
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KEYWORD
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Thrombotic thrombocytopenic purpura, Rituximab, Mitomycin, Plasma exchange
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